In cryogenic electron microscopy (cryo-EM) of radiation-sensitive biological samples. both the signal-to-noise ratio (SNR) and the contrast of images are critically important in the image-processing pipeline. Classic methods improve low-frequency image contrast experimentally. by imaging with high defocus. https://www.roneverhart.com/Joe-Moreira-Jiu-Jitsu-Course-1-On-Demand/
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