SARS-CoV-2 has spread very quickly from its first reported case on 19 January 2020 in the United Stated of America. leading WHO to declare pandemic by 11 March 2020. RNA viruses accumulate mutations following replication and passage in human population. which prompted us to determine the rate and the regions (hotspots) of the viral genome with high rates of mutation. https://yeswellneses.shop/product-category/digestive-enzymes/